Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Deregulation of innate immune TLR4 signaling contributes to various diseases including neuropathic pain and drug addiction. Naltrexone is one of the rare TLR4 antagonists with good blood-brain barrier permeability and showing no stereoselectivity for TLR4. By linking 2 naltrexone units through a rig...

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Библиографические подробности
Опубликовано в: :FASEB J
Главные авторы: Zhang, Xiaozheng, Peng, Yinghua, Grace, Peter M., Metcalf, Matthew D., Kwilasz, Andrew J., Wang, Yibo, Zhang, Tianshu, Wu, Siru, Selfridge, Brandon R., Portoghese, Philip S., Rice, Kenner C., Watkins, Linda R., Hutchinson, Mark R., Wang, Xiaohui
Формат: Artigo
Язык:Inglês
Опубликовано: Federation of American Societies for Experimental Biology 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988860/
https://ncbi.nlm.nih.gov/pubmed/31162938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900173RRR
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