Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Deregulation of innate immune TLR4 signaling contributes to various diseases including neuropathic pain and drug addiction. Naltrexone is one of the rare TLR4 antagonists with good blood-brain barrier permeability and showing no stereoselectivity for TLR4. By linking 2 naltrexone units through a rig...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Zhang, Xiaozheng, Peng, Yinghua, Grace, Peter M., Metcalf, Matthew D., Kwilasz, Andrew J., Wang, Yibo, Zhang, Tianshu, Wu, Siru, Selfridge, Brandon R., Portoghese, Philip S., Rice, Kenner C., Watkins, Linda R., Hutchinson, Mark R., Wang, Xiaohui
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988860/
https://ncbi.nlm.nih.gov/pubmed/31162938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900173RRR
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars