Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Deregulation of innate immune TLR4 signaling contributes to various diseases including neuropathic pain and drug addiction. Naltrexone is one of the rare TLR4 antagonists with good blood-brain barrier permeability and showing no stereoselectivity for TLR4. By linking 2 naltrexone units through a rig...

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Bibliografiska uppgifter
I publikationen:FASEB J
Huvudupphovsmän: Zhang, Xiaozheng, Peng, Yinghua, Grace, Peter M., Metcalf, Matthew D., Kwilasz, Andrew J., Wang, Yibo, Zhang, Tianshu, Wu, Siru, Selfridge, Brandon R., Portoghese, Philip S., Rice, Kenner C., Watkins, Linda R., Hutchinson, Mark R., Wang, Xiaohui
Materialtyp: Artigo
Språk:Inglês
Publicerad: Federation of American Societies for Experimental Biology 2019
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988860/
https://ncbi.nlm.nih.gov/pubmed/31162938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900173RRR
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