Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Deregulation of innate immune TLR4 signaling contributes to various diseases including neuropathic pain and drug addiction. Naltrexone is one of the rare TLR4 antagonists with good blood-brain barrier permeability and showing no stereoselectivity for TLR4. By linking 2 naltrexone units through a rig...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FASEB J
Egile Nagusiak: Zhang, Xiaozheng, Peng, Yinghua, Grace, Peter M., Metcalf, Matthew D., Kwilasz, Andrew J., Wang, Yibo, Zhang, Tianshu, Wu, Siru, Selfridge, Brandon R., Portoghese, Philip S., Rice, Kenner C., Watkins, Linda R., Hutchinson, Mark R., Wang, Xiaohui
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6988860/
https://ncbi.nlm.nih.gov/pubmed/31162938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900173RRR
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