Perlecan-targeted nanoparticles for drug delivery to triple-negative breast cancer

AIM: We previously developed two antibodies that bind to a cell surface protein, perlecan, overexpressed in triple-negative breast cancer (TNBC). The goal of this study was to investigate these antibodies as targeting ligands for nanoparticle-mediated drug delivery. METHODS: Paclitaxel-loaded poly(D...

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Veröffentlicht in:Future Drug Discov
Hauptverfasser: Khanna, Vidhi, Kalscheuer, Stephen, Kirtane, Ameya, Zhang, Wenqiu, Panyam, Jayanth
Format: Artigo
Sprache:Inglês
Veröffentlicht: Newlands Press Ltd 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700713/
https://ncbi.nlm.nih.gov/pubmed/31448368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/fdd-2019-0005
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