Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?

Lysosomal acid lipase (LAL) plays a key role in intracellular lipid metabolism. Reduced LAL activity promotes increased multi-organ lysosomal cholesterol ester storage, as observed in two recessive autosomal genetic diseases, Wolman disease and Cholesterol ester storage disease. Severe liver steatos...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Baratta, Francesco, Pastori, Daniele, Ferro, Domenico, Carluccio, Giovanna, Tozzi, Giulia, Angelico, Francesco, Violi, Francesco, Del Ben, Maria
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6700703/
https://ncbi.nlm.nih.gov/pubmed/31435171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v25.i30.4172
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