Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child

OBJECTIVES: Adverse physiology and antibiotic exposure devastate the intestinal microbiome in critical illness. Time and cost implications limit the immediate clinical potential of microbial sequencing to identify or treat intestinal dysbiosis. Here, we examined whether metabolic profiling is a feas...

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Dettagli Bibliografici
Pubblicato in:Crit Care Med
Autori principali: Wijeyesekera, Anisha, Wagner, Josef, De Goffau, Marcus, Thurston, Sarah, Rodrigues Sabino, Adilson, Zaher, Sara, White, Deborah, Ridout, Jenna, Peters, Mark J., Ramnarayan, Padmanabhan, Branco, Ricardo G., Torok, M. Estee, Valla, Frederic, Meyer, Rosan, Klein, Nigel, Frost, Gary, Parkhill, Julian, Holmes, Elaine, Pathan, Nazima
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2019
Soggetti:
Online Clinical Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699985/
https://ncbi.nlm.nih.gov/pubmed/31169619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003841
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