Multi-Compartment Profiling of Bacterial and Host Metabolites Identifies Intestinal Dysbiosis and Its Functional Consequences in the Critically Ill Child

OBJECTIVES: Adverse physiology and antibiotic exposure devastate the intestinal microbiome in critical illness. Time and cost implications limit the immediate clinical potential of microbial sequencing to identify or treat intestinal dysbiosis. Here, we examined whether metabolic profiling is a feas...

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Detalhes bibliográficos
Publicado no:Crit Care Med
Main Authors: Wijeyesekera, Anisha, Wagner, Josef, De Goffau, Marcus, Thurston, Sarah, Rodrigues Sabino, Adilson, Zaher, Sara, White, Deborah, Ridout, Jenna, Peters, Mark J., Ramnarayan, Padmanabhan, Branco, Ricardo G., Torok, M. Estee, Valla, Frederic, Meyer, Rosan, Klein, Nigel, Frost, Gary, Parkhill, Julian, Holmes, Elaine, Pathan, Nazima
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
Assuntos:
Online Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699985/
https://ncbi.nlm.nih.gov/pubmed/31169619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CCM.0000000000003841
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