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An extracellular acidic cleft confers profound H(+)-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevis

The limited sodium availability of freshwater and terrestrial environments was a major physiological challenge during vertebrate evolution. The epithelial sodium channel (ENaC) is present in the apical membrane of sodium-absorbing vertebrate epithelia and evolved as part of a machinery for efficient...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Wichmann, Lukas, Dulai, Jasdip Singh, Marles-Wright, Jon, Maxeiner, Stephan, Szczesniak, Pawel Piotr, Manzini, Ivan, Althaus, Mike
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699844/
https://ncbi.nlm.nih.gov/pubmed/31248986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008255
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