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An extracellular acidic cleft confers profound H(+)-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevis
The limited sodium availability of freshwater and terrestrial environments was a major physiological challenge during vertebrate evolution. The epithelial sodium channel (ENaC) is present in the apical membrane of sodium-absorbing vertebrate epithelia and evolved as part of a machinery for efficient...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6699844/ https://ncbi.nlm.nih.gov/pubmed/31248986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008255 |
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