PHARMACOPROTEOMICS REVEAL NOVEL PROTECTIVE ACTIVITY OF BROMODOMAIN CONTAINING 4 INHIBITORS ON VASCULAR HOMEOSTASIS IN TLR3-MEDIATED AIRWAY REMODELING

Small molecule inhibitors of the epigenetic regulator bromodomain-containing protein 4 (BRD4) are potential therapeutics for viral and allergen-induced airway remodeling. A limitation of their preclinical advancement is the lack of detailed understanding of mechanisms of action and biomarkers of eff...

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Détails bibliographiques
Publié dans:J Proteomics
Auteurs principaux: Zhao, Yingxin, Bing, Tian, Sun, Hong, Zhang, Jing, Zhang, Yueqing, Ivannikov, Maxim, Motamedi, Massoud, Liu, Zhiqing, Zhou, Jia, Kaphalia, Lata, Calhoun, William J., Maroto, Rosario, Brasier, Allan R
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699176/
https://ncbi.nlm.nih.gov/pubmed/31195152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2019.103415
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