Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ) receptor-expressing immune cells. We previ...

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Bibliografiske detaljer
Udgivet i:Antibodies (Basel)
Main Authors: Tam, Susan H., McCarthy, Stephen G., Armstrong, Anthony A., Somani, Sandeep, Wu, Sheng-Jiun, Liu, Xuesong, Gervais, Alexis, Ernst, Robin, Saro, Dorina, Decker, Rose, Luo, Jinquan, Gilliland, Gary L., Chiu, Mark L., Scallon, Bernard J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698826/
https://ncbi.nlm.nih.gov/pubmed/31548527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib6030012
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