Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality

Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ) receptor-expressing immune cells. We previ...

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Detalhes bibliográficos
Publicado no:Antibodies (Basel)
Main Authors: Tam, Susan H., McCarthy, Stephen G., Armstrong, Anthony A., Somani, Sandeep, Wu, Sheng-Jiun, Liu, Xuesong, Gervais, Alexis, Ernst, Robin, Saro, Dorina, Decker, Rose, Luo, Jinquan, Gilliland, Gary L., Chiu, Mark L., Scallon, Bernard J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698826/
https://ncbi.nlm.nih.gov/pubmed/31548527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib6030012
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