Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence

Pathogenic bacteria encounter host-imposed manganese (Mn) limitation during infection. Herein we report that in the human pathogen Streptococcus pyogenes, the adaptive response to Mn limitation is controlled by a DtxR family metalloregulator, MtsR. Genes upregulated by MtsR during Mn limitation incl...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Do, Hackwon, Makthal, Nishanth, Chandrangsu, Pete, Olsen, Randall J, Helmann, John D, Musser, James M, Kumaraswami, Muthiah
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Molecular Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6698748/
https://ncbi.nlm.nih.gov/pubmed/31188450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz524
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