Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

BACKGROUND: Cell-to-cell propagation of α-synuclein (α-syn) aggregates is thought to contribute to the pathogenesis of Parkinson’s disease (PD) and underlie the spread of α-syn neuropathology. Increased pro-inflammatory cytokine levels and activated microglia are present in PD and activated microgli...

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Publicado en:Mol Neurodegener
Autores principales: George, Sonia, Rey, Nolwen L., Tyson, Trevor, Esquibel, Corinne, Meyerdirk, Lindsay, Schulz, Emily, Pierce, Steven, Burmeister, Amanda R., Madaj, Zachary, Steiner, Jennifer A., Escobar Galvis, Martha L., Brundin, Lena, Brundin, Patrik
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697982/
https://ncbi.nlm.nih.gov/pubmed/31419995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0335-3
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