T Cells Limit Accumulation of Aggregate Pathology Following Intrastriatal Injection of α-Synuclein Fibrils

BACKGROUND: α-Synuclein (α-syn) is the predominant protein in Lewy-body inclusions, which are pathological hallmarks of α-synucleinopathies, such as Parkinson’s disease (PD) and multiple system atrophy (MSA). Other hallmarks include activation of microglia, elevation of pro-inflammatory cytokines, a...

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Publicado en:J Parkinsons Dis
Autores principales: George, Sonia, Tyson, Trevor, Rey, Nolwen L., Sheridan, Rachael, Peelaerts, Wouter, Becker, Katelyn, Schulz, Emily, Meyerdirk, Lindsay, Burmeister, Amanda R., von Linstow, Christian U., Steiner, Jennifer A., Galvis, Martha L. Escobar, Ma, Jiyan, Pospisilik, J. Andrew, Labrie, Viviane, Brundin, Lena, Brundin, Patrik
Formato: Artigo
Lenguaje:Inglês
Publicado: IOS Press 2021
Materias:
Research Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150548/
https://ncbi.nlm.nih.gov/pubmed/33579871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-202351
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