Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats

The α4β2 nAChR is the most predominant subtype in the brain and is a well-known culprit for nicotine addiction. Previously we presented a series of α4β2 nAChR selective compounds that were discovered from a mixture-based positional-scanning combinatorial library. Here we report further optimization...

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Udgivet i:J Med Chem
Main Authors: Wu, Jinhua, Cippitelli, Andrea, Zhang, Yaohong, Debevec, Ginamarie, Schoch, Jennifer, Ozawa, Akihiko, Yu, Yongping, Liu, Huan, Chen, Wenteng, Houghten, Richard A., Welmaker, Gregory S., Giulianotti, Marc A., Toll, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697865/
https://ncbi.nlm.nih.gov/pubmed/29178785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01250
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