Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes

High throughput omics approaches provide an unprecedented opportunity for dissecting molecular mechanisms in cancer biology. Here we present deep profiling of whole proteome, phosphoproteome and transcriptome in two high-grade glioma (HGG) mouse models driven by mutated RTK oncogenes, PDGFRA and NTR...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Hong, Diaz, Alexander K., Shaw, Timothy I., Li, Yuxin, Niu, Mingming, Cho, Ji-Hoon, Paugh, Barbara S., Zhang, Yang, Sifford, Jeffrey, Bai, Bing, Wu, Zhiping, Tan, Haiyan, Zhou, Suiping, Hover, Laura D., Tillman, Heather S., Shirinifard, Abbas, Thiagarajan, Suresh, Sablauer, Andras, Pagala, Vishwajeeth, High, Anthony A., Wang, Xusheng, Li, Chunliang, Baker, Suzanne J., Peng, Junmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697699/
https://ncbi.nlm.nih.gov/pubmed/31420543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11661-4
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