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Extensive Peptide Fractionation and y(1) Ion-based Interference Detection Enable Accurate Quantification by Isobaric Labeling and Mass Spectrometry
Isobaric labeling quantification by mass spectrometry (MS) has emerged as a powerful technology for multiplexed large-scale protein profiling, but measurement accuracy in complex mixtures is confounded by the interference from co-isolated ions, resulting in ratio compression. Here we report that the...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467445/ https://ncbi.nlm.nih.gov/pubmed/28194965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b04415 |
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