Extensive Peptide Fractionation and y(1) Ion-based Interference Detection Enable Accurate Quantification by Isobaric Labeling and Mass Spectrometry

Isobaric labeling quantification by mass spectrometry (MS) has emerged as a powerful technology for multiplexed large-scale protein profiling, but measurement accuracy in complex mixtures is confounded by the interference from co-isolated ions, resulting in ratio compression. Here we report that the...

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Bibliografiset tiedot
Julkaisussa:Anal Chem
Päätekijät: Niu, Mingming, Cho, Ji-Hoon, Kodali, Kiran, Pagala, Vishwajeeth, High, Anthony A., Wang, Hong, Wu, Zhiping, Li, Yuxin, Bi, Wenjian, Zhang, Hui, Wang, Xusheng, Zou, Wei, Peng, Junmin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467445/
https://ncbi.nlm.nih.gov/pubmed/28194965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.6b04415
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