The next generation BET inhibitor, PLX51107, delays melanoma growth in a CD8-mediated manner

Epigenetic agents such as bromodomain and extra terminal region inhibitors (BETi) slow tumor growth via tumor intrinsic alterations; however, their effects on anti-tumor immunity remain unclear. A recent advance is the development of next generation BETi that are potent and display a favorable half-...

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Vydáno v:Pigment Cell Melanoma Res
Hlavní autoři: Erkes, Dan A., Field, Conroy O., Capparelli, Claudia, Tiago, Manoela, Purwin, Timothy J., Chervoneva, Inna, Berger, Adam C., Hartsough, Edward J., Villanueva, Jessie, Aplin, Andrew E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697571/
https://ncbi.nlm.nih.gov/pubmed/31063649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12788
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