CD24 signalling through macrophage Siglec-10 is a new target for cancer immunotherapy

Ovarian cancer and triple-negative breast cancer (TNBC) are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Here we show that CD24 can be the dominant innate immune checkpoint in ovarian cancer and breast cancer, and is a new, promising targe...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Barkal, Amira A, Brewer, Rachel E., Markovic, Maxim, Kowarsky, Mark, Barkal, Sammy A, Zaro, Balyn W., Krishnan, Venkatesh, Hatakeyama, Jason, Dorigo, Oliver, Barkal, Layla J, Weissman, Irving L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697206/
https://ncbi.nlm.nih.gov/pubmed/31367043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1456-0
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