Transcriptomic Profiling of the Tumor Microenvironment Reveals Distinct Subgroups of Clear Cell Renal Cell Cancer - Data from a Randomized Phase III Trial

Metastasis remains the main reason for renal cell carcinoma (RCC)-associated mortality. Tyrosine kinase inhibitors (TKI) impart clinical benefit for most RCC patients but the determinants of response are poorly understood. We report an integrated genomic and transcriptomic analysis of metastatic cle...

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Veröffentlicht in:Cancer Discov
Hauptverfasser: Hakimi, A. Ari, Voss, Martin H., Kuo, Fengshen, Sanchez, Alejandro, Liu, Ming, Nixon, Briana, Vuong, Lynda, Ostrovnaya, Irina, Chen, Ying Bei, Reuter, Victor E., Riaz, Nadeem, Cheng, Yuan, Patel, Parul, Marker, Mahtab, Reising, Albert, Li, Ming, Chan, Timothy A., Motzer, Robert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6697163/
https://ncbi.nlm.nih.gov/pubmed/30622105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0957
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