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The Development of Tetrazole Derivatives as Protein Arginine Methyltransferase I (PRMT I) Inhibitors

Protein arginine methyltransferase 1 (PRMT1) can catalyze protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein arginine, which influences a variety of biological processes. The dysregulation of PRMT1 is involved in...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Sun, Yutong, Wang, Zhe, Yang, Hao, Zhu, Xuanli, Wu, Han, Ma, Lu, Xu, Fang, Hong, Wei, Wang, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695598/
https://ncbi.nlm.nih.gov/pubmed/31390828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20153840
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