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Influenza Virus with Increased pH of Hemagglutinin Activation Has Improved Replication in Cell Culture but at the Cost of Infectivity in Human Airway Epithelium

Pandemic H1N1 (pH1N1) influenza virus emerged from swine in 2009 with an adequate capability to infect and transmit between people. In subsequent years, it has circulated as a seasonal virus and evolved further human-adapting mutations. Mutations in the hemagglutinin (HA) stalk that increase pH stab...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Singanayagam, Anika, Zambon, Maria, Barclay, Wendy S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694820/
https://ncbi.nlm.nih.gov/pubmed/31189708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00058-19
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