Monoclonal Antibody 2C6 Targets a Cross-Clade Conformational Epitope in gp41 with Highly Active Antibody-Dependent Cell Cytotoxicity

Previous studies in our laboratory characterized a panel of highly mutated HIV-specific conformational epitope-targeting antibodies (Abs) from a panel of HIV-infected long-term nonprogressors (LTNPs). Despite binding HIV envelope protein and having a high number of somatic amino acid mutations, thes...

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Vydáno v:J Virol
Hlavní autoři: Sojar, Hakimuddin, Baron, Sarah, Sullivan, Jonathan T., Garrett, Meghan, van Haaren, Marlies M., Hoffman, Jonathon, Overbaugh, Julie, Doranz, Benjamin J., Hicar, Mark D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694811/
https://ncbi.nlm.nih.gov/pubmed/31217246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00772-19
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