A Phase Ib Study of the Combination of Personalized Autologous Dendritic Cell Vaccine, Aspirin, and Standard of Care Adjuvant Chemotherapy Followed by Nivolumab for Resected Pancreatic Adenocarcinoma—A Proof of Antigen Discovery Feasibility in Three Patients

Despite the promising therapeutic effects of immune checkpoint blockade (ICB), most patients with solid tumors treated with anti-PD-1/PD-L1 monotherapy do not achieve objective responses, with most tumor regressions being partial rather than complete. It is hypothesized that the absence of pre-exist...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bassani-Sternberg, Michal, Digklia, Antonia, Huber, Florian, Wagner, Dorothea, Sempoux, Christine, Stevenson, Brian J., Thierry, Anne-Christine, Michaux, Justine, Pak, HuiSong, Racle, Julien, Boudousquie, Caroline, Balint, Klara, Coukos, George, Gfeller, David, Martin Lluesma, Silvia, Harari, Alexandre, Demartines, Nicolas, Kandalaft, Lana E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694698/
https://ncbi.nlm.nih.gov/pubmed/31440238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01832
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