An enhanced genetic model of colorectal cancer progression history

BACKGROUND: The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomic alterations, such as genomic rearrangements, are still u...

Full description

Saved in:
Bibliographic Details
Published in:Genome Biol
Main Authors: Yang, Lixing, Wang, Su, Lee, Jake June-Koo, Lee, Semin, Lee, Eunjung, Shinbrot, Eve, Wheeler, David A., Kucherlapati, Raju, Park, Peter J.
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694562/
https://ncbi.nlm.nih.gov/pubmed/31416464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1782-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items