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An enhanced genetic model of colorectal cancer progression history

BACKGROUND: The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomic alterations, such as genomic rearrangements, are still u...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Yang, Lixing, Wang, Su, Lee, Jake June-Koo, Lee, Semin, Lee, Eunjung, Shinbrot, Eve, Wheeler, David A., Kucherlapati, Raju, Park, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694562/
https://ncbi.nlm.nih.gov/pubmed/31416464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1782-4
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