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Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK-mTOR pathway
BACKGROUND: To investigate the mechanism underlying the chondroprotective effect of estrogen in AMP-activated protein kinase (AMPK) deficiency mice. METHODS: Female cartilage-specific AMPKα double knockout (AMPKα cDKO) mice were generated and subjected to ovariectomy (OVX). The model of osteoarthrit...
Shranjeno v:
| izdano v: | Ann Transl Med |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
AME Publishing Company
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6694256/ https://ncbi.nlm.nih.gov/pubmed/31475206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.06.77 |
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