Estrogen prevents articular cartilage destruction in a mouse model of AMPK deficiency via ERK-mTOR pathway

BACKGROUND: To investigate the mechanism underlying the chondroprotective effect of estrogen in AMP-activated protein kinase (AMPK) deficiency mice. METHODS: Female cartilage-specific AMPKα double knockout (AMPKα cDKO) mice were generated and subjected to ovariectomy (OVX). The model of osteoarthrit...

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Publicat a:Ann Transl Med
Autors principals: Ge, Yuxiang, Zhou, Sheng, Li, Yixuan, Wang, Zixu, Chen, Shuai, Xia, Tianwei, Shen, Jirong, Teng, Huajian, Jiang, Qing
Format: Artigo
Idioma:Inglês
Publicat: AME Publishing Company 2019
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6694256/
https://ncbi.nlm.nih.gov/pubmed/31475206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2019.06.77
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