The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice

BACKGROUND: The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by mu-opioid receptors (MORs) in the CNS. Based on our prior observation that morphine and delta-opioid receptor (DOR) agonists synergiz...

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Bibliografiska uppgifter
I publikationen:Anesthesiology
Huvudupphovsmän: Bruce, Daniel.J., Peterson, Cristina.D., Kitto, Kelley. F., Akgün, Eyup., Lazzaroni, Sophia., Portoghese, Phillip.S., Fairbanks, Carolyn. A., Wilcox, George. L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693899/
https://ncbi.nlm.nih.gov/pubmed/31343460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002840
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