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The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice
BACKGROUND: The long-term use of opioids for analgesia carries significant risk for tolerance, addiction, and diversion. These adverse effects are largely mediated by mu-opioid receptors (MORs) in the CNS. Based on our prior observation that morphine and delta-opioid receptor (DOR) agonists synergiz...
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| Publicado en: | Anesthesiology |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693899/ https://ncbi.nlm.nih.gov/pubmed/31343460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002840 |
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