Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways

Resuscitation with 0.9% Normal Saline (NS), a non-buffered acidic solution, leads to increased morbidity and mortality in the critically ill. The goal of this study was to determine the molecular mechanisms of endothelial injury after exposure to NS. The hypothesis of this investigation is that expo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cheung-Flynn, Joyce, Alvis, Bret D., Hocking, Kyle M., Guth, Christy M., Luo, Weifeng, McCallister, Reid, Chadalavada, Kalyan, Polcz, Monica, Komalavilas, Padmini, Brophy, Colleen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693757/
https://ncbi.nlm.nih.gov/pubmed/31412063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0220893
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