The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase

The NRF2 transcription factor controls a cell stress program that is implicated in cancer and there is great interest in targeting NRF2 for therapy. We show that NRF2 activity depends on Fructosamine-3-kinase (FN3K) - a kinase that triggers protein de-glycation. In its absence, NRF2 is extensively g...

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Publicado en:Cell
Autores principales: Sanghvi, Viraj R., Leibold, Josef, Mina, Marco, Mohan, Prathibha, Berishaj, Marjan, Li, Zhuoning, Miele, Matthew M., Lailler, Nathalie, Zhao, Chunying, de Stanchina, Elisa, Viale, Agnes, Akkari, Leila, Lowe, Scott W., Ciriello, Giovanni, Hendrickson, Ronald C., Wendel, Hans-Guido
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693658/
https://ncbi.nlm.nih.gov/pubmed/31398338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.07.031
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