The anti-inflammatory protein TNFAIP3/A20 binds the WD40 domain of ATG16L1 to control the autophagic response, NFKB/NF-κB activation and intestinal homeostasis

The C-terminal domain of ATG16L1 includes 7 WD40-type repeats (WD40 domain, WDD) and is not required for canonical macroautophagy/autophagy. Instead, the WDD allows ATG16L1 to induce LC3/Atg8 lipidation in single-membrane compartments, although a detailed functional characterization of this region i...

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Publicat a:Autophagy
Autors principals: Serramito-Gómez, Inmaculada, Boada-Romero, Emilio, Slowicka, Karolina, Vereecke, Lars, Van Loo, Geert, Pimentel-Muiños, Felipe X.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
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Commentary
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6693451/
https://ncbi.nlm.nih.gov/pubmed/31184523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1628549
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