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Application of chiral 2-isoxazoline for the synthesis of syn-1,3-diol analogs
The asymmetric cycloaddition of TIPS nitronate catalyzed by “Cu(II)-bisoxazoline” gave the 2-isoxazoline product in 95% yield, which was converted into tert-butyl (3S,5R)-6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate in 14 steps through a β-hydroxy ketone.
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| Udgivet i: | Beilstein J Org Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Beilstein-Institut
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693402/ https://ncbi.nlm.nih.gov/pubmed/31467605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.179 |
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