Topical Administration of a Soluble TNF Inhibitor Reduces Infarct Volume After Focal Cerebral Ischemia in Mice

BACKGROUND: Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. The objective of the present study was to test the effect of topical versus intracerebroventricular administration of XPro1595 (a solTN...

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Udgivet i:Front Neurosci
Main Authors: Yli-Karjanmaa, Minna, Clausen, Bettina Hjelm, Degn, Matilda, Novrup, Hans Gram, Ellman, Ditte Gry, Toft-Jensen, Peter, Szymkowski, David E., Stensballe, Allan, Meyer, Morten, Brambilla, Roberta, Lambertsen, Kate Lykke
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692878/
https://ncbi.nlm.nih.gov/pubmed/31440125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00781
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