Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic-euglycemic clamps in three participant groups (n...

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Опубликовано в: :Diabetes
Главные авторы: Gregory, Justin M., Smith, T. Jordan, Slaughter, James C., Mason, Holly R., Hughey, Curtis C., Smith, Marta S., Kandasamy, Balamurugan, Greeley, Siri Atma W., Philipson, Louis H., Naylor, Rochelle N., Letourneau, Lisa R., Abumrad, Naji N., Cherrington, Alan D., Moore, Daniel J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2019
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692813/
https://ncbi.nlm.nih.gov/pubmed/31092478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0324
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