Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic-euglycemic clamps in three participant groups (n...

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Vydáno v:Diabetes
Hlavní autoři: Gregory, Justin M., Smith, T. Jordan, Slaughter, James C., Mason, Holly R., Hughey, Curtis C., Smith, Marta S., Kandasamy, Balamurugan, Greeley, Siri Atma W., Philipson, Louis H., Naylor, Rochelle N., Letourneau, Lisa R., Abumrad, Naji N., Cherrington, Alan D., Moore, Daniel J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2019
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692813/
https://ncbi.nlm.nih.gov/pubmed/31092478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0324
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