Iatrogenic Hyperinsulinemia, Not Hyperglycemia, Drives Insulin Resistance in Type 1 Diabetes as Revealed by Comparison With GCK-MODY (MODY2)

Although insulin resistance consistently occurs with type 1 diabetes, its predominant driver is uncertain. We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic-euglycemic clamps in three participant groups (n...

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Bibliografske podrobnosti
izdano v:Diabetes
Main Authors: Gregory, Justin M., Smith, T. Jordan, Slaughter, James C., Mason, Holly R., Hughey, Curtis C., Smith, Marta S., Kandasamy, Balamurugan, Greeley, Siri Atma W., Philipson, Louis H., Naylor, Rochelle N., Letourneau, Lisa R., Abumrad, Naji N., Cherrington, Alan D., Moore, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2019
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692813/
https://ncbi.nlm.nih.gov/pubmed/31092478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db19-0324
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