Association of CAG Repeats With Long-term Progression in Huntington Disease

IMPORTANCE: In Huntington disease (HD), mutation severity is defined by the length of the CAG trinucleotide sequence, a well-known predictor of clinical onset age. The association with disease trajectory is less well characterized. Quantifiable summary measures of trajectory applicable over decades...

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Bibliografiska uppgifter
I publikationen:JAMA Neurol
Huvudupphovsmän: Langbehn, Douglas R., Stout, Julie C., Gregory, Sarah, Mills, James A., Durr, Alexandra, Leavitt, Blair R., Roos, Raymund A. C., Long, Jeffrey D., Owen, Gail, Johnson, Hans J., Borowsky, Beth, Craufurd, David, Reilmann, Ralf, Landwehrmeyer, G. Bernhard, Scahill, Rachael I., Tabrizi, Sarah J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Medical Association 2019
Ämnen:
Original Investigation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692683/
https://ncbi.nlm.nih.gov/pubmed/31403680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.2368
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