Ancestral reconstruction reveals mechanisms of ERK regulatory evolution

Protein kinases are crucial to coordinate cellular decisions and therefore their activities are strictly regulated. Previously we used ancestral reconstruction to determine how CMGC group kinase specificity evolved (Howard et al., 2014). In the present study, we reconstructed ancestral kinases to st...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sang, Dajun, Pinglay, Sudarshan, Wiewiora, Rafal P, Selvan, Myvizhi E, Lou, Hua Jane, Chodera, John D, Turk, Benjamin E, Gümüş, Zeynep H, Holt, Liam J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692128/
https://ncbi.nlm.nih.gov/pubmed/31407663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38805
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