Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

PURPOSE: The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark of aged RPE. Lipofuscin derives, in part, from the incomplete degradation of phagocytized photoreceptor outer segments (OS). Whether this accumulated waste is toxic is unclear. We there...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Zhang, Qitao, Presswalla, Feriel, Calton, Melissa, Charniga, Carol, Stern, Jeffrey, Temple, Sally, Vollrath, Douglas, Zacks, David N., Ali, Robin R., Thompson, Debra A., Miller, Jason M. L.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2019
Fag:
Retinal Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692057/
https://ncbi.nlm.nih.gov/pubmed/31408109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-26690
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