Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

PURPOSE: The accumulation of undigestible autofluorescent material (UAM), termed lipofuscin in vivo, is a hallmark of aged RPE. Lipofuscin derives, in part, from the incomplete degradation of phagocytized photoreceptor outer segments (OS). Whether this accumulated waste is toxic is unclear. We there...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Invest Ophthalmol Vis Sci
Egile Nagusiak: Zhang, Qitao, Presswalla, Feriel, Calton, Melissa, Charniga, Carol, Stern, Jeffrey, Temple, Sally, Vollrath, Douglas, Zacks, David N., Ali, Robin R., Thompson, Debra A., Miller, Jason M. L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Association for Research in Vision and Ophthalmology 2019
Gaiak:
Retinal Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692057/
https://ncbi.nlm.nih.gov/pubmed/31408109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-26690
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