MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis

Low temperatures delay aging and promote longevity in many organisms. However, the metabolic and homeostatic aspects of low-temperature–induced longevity remain poorly understood. Here, we show that lipid homeostasis regulated by Caenorhabditis elegans Mediator 15 (MDT-15 or MED15), a transcriptiona...

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Vydáno v:PLoS Biol
Hlavní autoři: Lee, Dongyeop, An, Seon Woo A., Jung, Yoonji, Yamaoka, Yasuyo, Ryu, Youngjae, Goh, Grace Ying Shyen, Beigi, Arshia, Yang, Jae-Seong, Jung, Gyoo Yeol, Ma, Dengke K., Ha, Chang Man, Taubert, Stefan, Lee, Youngsook, Lee, Seung-Jae V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692015/
https://ncbi.nlm.nih.gov/pubmed/31408455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000415
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