Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans

Zinc is essential for cellular functions as it is a catalytic and structural component of many proteins. In contrast, cadmium is not required in biological systems and is toxic. Zinc and cadmium levels are closely monitored and regulated as their excess causes cell stress. To maintain homeostasis, o...

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發表在:PLoS Genet
Main Authors: Shomer, Naomi, Kadhim, Alexandre Zacharie, Grants, Jennifer Margaret, Cheng, Xuanjin, Alhusari, Deema, Bhanshali, Forum, Poon, Amy Fong-Yuk, Lee, Michelle Ying Ya, Muhuri, Anik, Park, Jung In, Shih, James, Lee, Dongyeop, Lee, Seung-Jae V., Lynn, Francis Christopher, Taubert, Stefan
格式: Artigo
語言:Inglês
出版: Public Library of Science 2019
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6922464/
https://ncbi.nlm.nih.gov/pubmed/31815936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008508
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