Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts a...

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Publicat a:Epigenetics
Autors principals: Sturm, Gabriel, Cardenas, Andres, Bind, Marie-Abèle, Horvath, Steve, Wang, Shuang, Wang, Yunzhang, Hägg, Sara, Hirano, Michio, Picard, Martin
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691995/
https://ncbi.nlm.nih.gov/pubmed/31156022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1626651
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