Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Epigenetics
Main Authors: Sturm, Gabriel, Cardenas, Andres, Bind, Marie-Abèle, Horvath, Steve, Wang, Shuang, Wang, Yunzhang, Hägg, Sara, Hirano, Michio, Picard, Martin
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2019
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691995/
https://ncbi.nlm.nih.gov/pubmed/31156022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1626651
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