Prolactin signaling drives tumorigenesis in human high grade serous ovarian cancer cells and in a spontaneous fallopian tube derived model

The pathways responsible for tumorigenesis of high grade serous ovarian cancer (HGSOC) from the fallopian tube epithelium (FTE) are still poorly understood. A human prolactin (PRL) like gene, Prl2c2 was amplified > 100 fold in a spontaneous model of FTE-derived ovarian cancer (MOE(high) - murine...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Karthikeyan, Subbulakshmi, Russo, Angela, Dean, Matthew, Lantvit, Daniel D., Endsley, Michael, Burdette, Joanna E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691889/
https://ncbi.nlm.nih.gov/pubmed/29981811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.07.003
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