Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes

OBJECTIVE: A hallmark of amyotrophic lateral sclerosis (ALS) caused by mutations in superoxide dismutase-1 (SOD1) are inclusions containing SOD1 in motor neurons. Here, we searched for SOD1-positive inclusions in 29 patients carrying ALS-linked mutations in six other genes. METHODS: A panel of antib...

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Bibliografiska uppgifter
I publikationen:J Neurol Neurosurg Psychiatry
Huvudupphovsmän: Forsberg, Karin, Graffmo, Karin, Pakkenberg, Bente, Weber, Markus, Nielsen, Martin, Marklund, Stefan, Brännström, Thomas, Andersen, Peter Munch
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMJ Publishing Group 2019
Ämnen:
Neurodegeneration
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691870/
https://ncbi.nlm.nih.gov/pubmed/30992335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2018-319386
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