Hybrid micelles containing methotrexate-conjugated polymer and co-loaded with microRNA-124 for rheumatoid arthritis therapy

Purpose: Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA)therapy. However, MTX monotherapy often results in irreversible joint damage due to its slow onset of action and long duration. microRNA-124 (miR-124) has shown direct bone protection activity against RA. A co-delivery sys...

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Publicat a:Theranostics
Autors principals: Hao, Fei, Lee, Robert J, Zhong, Lihuang, Dong, Shiyan, Yang, Chunmiao, Teng, Lirong, Meng, Qingfan, Lu, Jiahui, Xie, Jing, Teng, Lesheng
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6691571/
https://ncbi.nlm.nih.gov/pubmed/31410215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32268
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