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Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3
[Image: see text] Neutrophils produce at least four serine proteases that are packaged within azurophilic granules. These enzymes contribute to antimicrobial defense and inflammation but can be destructive if their activities are not properly regulated. Accordingly, they represent therapeutic target...
Guardat en:
| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2019
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6691563/ https://ncbi.nlm.nih.gov/pubmed/31413811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00253 |
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